Research

Developmental and Cancer Cell Biology

We use genetic and biochemical approaches to decipher molecular mechanisms that coordinate growth and differentiation of cells and tissues during normal development and in cancer. A current focus is on live imaging of proprotein convertases and their roles in regulating TGFβ-related activities and other specific signaling pathways in tumour cells and in their microenvironment. We also study the regulation of mRNA translation and cell metabolism by the RNA-binding protein Bicc1 and specific interacting factors. Mutations in Bicc1 randomize visceral left-right asymmetry and instigate cystic growth in the kidney and pancreas. Identifying upstream regulators and relevant downstream targets of Bicc1 will shed light on the etiology of polycystic kidney diseases.

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